Graphical User Interface

Creating, editing and simulating a spatial model is all done using a user friendly Graphical User Interface. See the Getting Started section in the documentation to learn more.

DuneCopasi FEM Solver

The dune-copasi solver is used to simulate models. This solves the PDE on a triangular mesh using finite element discretization methods. See the simulator documentation for more information on the available options when using it in the GUI. For more technical information about the DuneCopasi solver itself, see the dune-copasi website.

Automatic mesh generation

Starting from a segmented image of the compartments in the model, the boundaries are automatically identified and simplified, and from them a triangular mesh approximation to the geometry is constructed. For more details see the mesh documentation.

Pixel FTCS Solver

The Pixel solver is an alternative solver which uses the FTCS method to solve the PDE using the pixels of the geometry image as the grid. It features automatic timestep control, just-in-time compilation, and multi-threading support.

Python interface

The Python interface, sme, allows scripted editing and simulation of a model. See the Example Notebooks or the API reference for more information.

Python extras

Additional functionality such as plotting, animations and parameter fitting is provided by sme-contrib. See the documentation for more information and example notebooks.

SBML Spatial

Spatial models are imported and exported in SBML Level 3 format with the spatial package, using the libSBML library. All Level 3 math is supported, and is parsed, differentiated and compiled using the SymEngine symbolic manipulation library.

Automatic reaction rescaling

Guided workflow to import a non-spatial model from SBML xml or Copasi cps format, which automatically rescales the reaction rates to construct a valid spatial PDE model that initially reproduces the behaviour of the non-spatial ODE model.